The Chameleon also has similar traits to the Inspector Gadget villain Prest-O Change-O, also known as "The Human Chameleon".
Dudley and an Unnamed Rabbit Cop once referred to the Chameleon as the "Cham-ah-lee-on", which the Chameleon himself also mispronounces later once.
He is the villain who is picked-on most for his near awkward and obsessive behavior. He is willing to be friends with characters on both sides of the spectrum; D.O.O.M. and T.U.F.F. both, and neither one of them seem to enjoy his presence.
The whole moving eyes thing is an attribute of real chameleons.
Every time he is seen working with another villain, they take advantage of him. In the episode Mission: Really Big Mission, Snaptrap uses him as a cupholder, box of tissues, and a toothpick. The Chameleon of course doesn't seem to mind because he feels like he is "helping."
When the Chameleon is shape-shifting, he is all bionic like his suit and his eyes are red and straight.
A running gag is that every time he is seen, he wears some kind of eyewear that usually either breaks or that doesn't usually fit over his eyes.
Sometimes, he changes his voice based on the audience's knowledge of what's going on the show. One example is in the episode "Share-A-Lair". He changes his voice when he turns into Agent Rodentski, but he doesn't change his voice when he turns back into Agent Rodentski later on in the episode.
We've seen the Chameleon three times without the molecular transformation suit, and that's in "Puppy Love" (prison uniform), "Guard Dog" (his underwear), and "Diary of a Mad Cat" (a hat, sunglasses, a purple shirt and red swimming shorts). It's possibly rare for the Chameleon to be seen without his Molecular Transformation Suit, but three times the charm.