In his office at T.U.F.F., The Chief is seen watching videos of himself when a shrunken Dudley comes in and tells him that he has a "little problem". We learn that Dudley accidentally shrunk himself with a shrink ray so that he could have a giant cookie. In this moment, The Chief tells Dudley that he was the best agent of T.U.F.F., and Dudley is in his best moment. General Warthog calls The Chief and says that he was kidnapped by The Chameleon, The Chief tells Dudley that he and Kitty must save the General, but Dudley says that Kitty lost a bet and had to take Keswick with her to the movies, but Dudley had a idea and asks The Chief if he can go with him, but The Chief refuses, after many tries The Chief accepts and goes to The Chameleon's house where his plan is to redirect the missile test to T.U.F.F. HQ, transformed into General Warthog, but first he ate the Mini-pizza bagels.
The Chief tries to stop him, but The Chameleon ate The Chief; Dudley tries to rescue the him, but the result is the same. Meanwhile Kitty and Keswick are at the cinema (part of the bet), and they turn off their blasters and wristcom, Dudley tried to connect with them but he can't, meanwhile The Chief tries to communicate with Dudley, but it's use-less because he is eaten too. The Chief is angry with Dudley for convincing him to join the mission. Dudley reassures the Chief that they would find a way out; he punches The Chameleon's stomach but is useless, in this moment he asks The Chief what would Super Agent Herbert Dumbrowski do (The Chief's real name) in this situation; he answers by saying that he would use his nun-chucks, but that only caused The Chameleon to eat a spider, in this moment they (accidentally) go to The Chameleon's heart but only to put it on fire, causing The Chameleon to drink a lot of water.
Afterwards, Dudley and The Chief arrive at The Chameleon's brain and Kitty and Keswick call them at this moment, Dudley ask them what they could do to stop the missile launch test, and Keswick says that the Molecular Transformation Suit is connected to The Chameleon's brain. Dudley and The Chief jump on the brain, trying to break the Molecular Transformation Suit (make him cannot control himself) but it's too high, Dudley then gets an idea and asks The Chief about his bionic foot. The Chief answers sarcastically, and Dudley tells him to use his foot to destroy the plug. The Chief manages to disconnect it, but it's too late; the missile was launched, but they don't worry about it (because Kitty and Keswick are taking care of it) and they exit The Chameleon's body. The Chameleon tries to eat them again but The Chief defeats him and Dudley cheers, meanwhile Kitty and Keswick believe they can't stop the missile and Keswick indicates Kitty that she use the Air Brake (Keswick was joking) and the missile was successfully stopped.
The episode ends in a ceremony to celebrate The Chief's triumph, but he and General Warthog fell asleep and Dudley's grossed by the General's dentures. Keswick returns him to his normal size, but only to transform Dudley into a Cerberus (Greek Mythological Hellhound) and Keswick says that he really needs to label his stuff.